In Vivo Neurophysiology
Christiaan de Kock
The cortex consists of many different cell-types but the function of these cell-types during behavior remains largely enigmatic. Our lab therefore aims to reveal the contribution of individual cortical layers and cell-types to cognitive performance.
The behavior we aim to understand (and the contribution of cortical cell-types to this behavior) is the gap-crossing task by rodents. This task involves 1) detecting a platform with its whiskers, 2) determine the position of the platform in 3D space and then 3) decide whether it is save to jump or not. We are studying the cellular basis of this sensory-guided cognitive behavior at the level of primary somatosensory cortex (S1), posterior parietal cortex (PPC) and prefrontal cortex (PFC).
Extremely little is known about the morphological and physiological properties of adult human neurons. Together with the lab of Huibert Mansvelder, our lab is investigating the relationship between structure and function of individual neurons across all layers in adult human cortex, obtained during resection surgery in the VU medical center (Amsterdam, the Netherlands).
We developed a novel pipeline to handle living brain tissue and preserve resected human brain material for the study of fundamental neurophysiological properties such as passive and active membrane properties, synaptic transmission, spike-timing-dependent (associative) plasticity and action potential back propagation.
Our lab is embedded in the department of Integrative Neurophysiology (Chair prof.dr. Huib Mansvelder), of the Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam (NCA), VU University Amsterdam.
Mohan et al, CerebCtx 2015
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